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Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells[J]

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Individuals (including pediatric patients) taking semaglutide must be monitored closely to ensure they do not become depressed or suicidal

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Injections also reach the dose levels used in the largest weight-loss trials

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