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The quality of evidence varies because PRP preparation methods differ between providers, making it hard to compare studies directly

Pregnant and breastfeeding women, people who regularly take medication and people with illnesses requiring treatment should consult their doctor before consumption

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Last and most importantly, it is know to counteract the unwanted bleeding effects, catalepsy, and somatosensory disturbances of NSAIDs (i.e Ibuprofen) as well as many heart drug medications