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By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, which thus remains available for recycling to NAD+ via the salvage pathway

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Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Whether applied to studies of aging biology, exercise physiology, cancer metabolism, or fundamental cellular energetics, 5-amino-1MQ provides the precision and reliability required for advancing our understanding of how metabolic networks integrate to maintain cellular and organismal health

doi:10.1096/fj.09-142307 Malinda KM, Goldstein AL, Kleinman HK