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For typical GERD symptoms, an 8-week trial of once-daily PPI therapy is standard, followed by using the lowest effective dose for maintenance if needed

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Clinicians should set realistic expectations during the informed consent process, emphasizing that digestive side effects are expected but usually transient and often improve with continued treatment

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This may influence several physiological functions including, but not restricted to, lowering both pre- and afterload of the heart and downregulation of sympathetic activity, and decreased intraglomerular pressure which is believed to be mediated by increased tubuloglomerular feedback

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Duration : Effects generally last between 4-14 days, depending on your stress levels, overall health, and individual metabolism

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A recent study published by researchers from the University of British Columbia shows that compared to bupropion-naltrexone, patients on GLP-1 agonist drugs present a 4.22 times higher risk of bowel obstruction

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