Unlike a standard 2.5 mg or 5 mg start, microdosing may begin as low as 0.25 mg
Major insurers covering these treatments include UnitedHealthcare, Blue Cross Blue Shield, Aetna, and Medicare Part D, among others
doi: 10.3389/fnbeh.2026.1805953 Received 06 February 2026 Revised 13 March 2026 Accepted 13 March 2026 Published 13 April 2026 Volume 20 - 2026 Edited by Emmanuel Darcq, Institut National de la Sant et de la Recherche Mdicale (INSERM), France Reviewed by Zhe Zhao, Max Planck Florida Institute for Neuroscience (MPFI), United States Madhawi Aldhwayan, King Saud University, Saudi Arabia Updates Copyright 2026 OConnor
Typical weight loss during this phase is 3 to 6 pounds cumulative
The caffeine irritates the stomach