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Research from the University of Arizona College of Medicine found that more than 60% of peptide research protocols using short-half-life secretagogues administered compounds outside their effective plasma windows

For influenza virus, the ability of HA stem-targeting nAbs to induce ADCC but their rather weak neutralizing activity compared with nAbs to the HA head domain, which have weak interaction as immune complexes with FcRs but potent neutralizing activity, probably explains the dependence of anti-stem nAbs (but not anti-head nAbs) on Fc-dependent effector functions for protective efficacy 173

In vitro, rodent, or human

The protein digestion challenge

J Am Heart Assoc 2016, 5