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Gonadorelin, a synthetic GnRH analog, is used experimentally to replace pulsatile GnRH signaling when it is deficient

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MGF and Large Animal Cardiac Research In sheep treated with the MGF E-domain peptide following microsphere-induced myocardial infarction, cardiac function improved in MGF E-domain-treated animals versus vehicle controls, with 35% less compromised cardiac muscle, absent immunostaining for cleaved caspase-3, and preservation of both systolic and diastolic function leading the authors to conclude that the E domain of MGF protects the myocardium against ischaemia and improves cardiac function post-MI

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