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Womack CJ, Saunders MJ, Bechtel MK, Bolton DJ, Martin M, Luden ND et al (2012) The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine

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Quick Answer: Tirzepatide likely has minimal direct blood-brain barrier penetration due to its large molecular size (approximately 4,800 daltons), but produces central nervous system effects through indirect pathways