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Recently, the STEP-HFpEF trial enrolled 529 non-diabetic patients with HFpEF and obesity, who were randomly assigned to receive either once-weekly semaglutide (2.4 mg) or placebo for 52 weeks

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Beyond its key role in skeletal homeostasis, several recent studies suggest extra-skeletal effects, such as a role as an immunomodulator in both adaptive and innate immune responses [102]

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