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Kong P, Christia P, Frangogiannis NG

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

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muciniphila may shape this SCFA milieu, thereby coupling microbial metabolism to barrier-protective epithelial-immune programs that sustain mucosal homeostasis under inflammatory stress 105

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