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No human safety data exists for these populations

The comparison between GLP-1RA and SGLT-2 inhibitors shows no difference in their risk for nonfatal MI (RR = 1.04, 95% CI 0.921.19)

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For Humana commercial plans, the 2026 PA criteria require five elements: BMI of 30 or higher, or BMI 27 to 29.9 with at least one weight-related comorbidity (type 2 diabetes, hypertension, dyslipidemia, OSA, CVD), documentation of a structured weight management program for at least 6 months in the past 24 months, prescriber attestation that lifestyle changes alone have been inadequate, age 18 or older, and concurrent reduced-calorie diet and physical activity