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Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A

135 described a pathway involving amino-acid- but not insulin-stimulated binding of the small GTPase Rab1A and mTORC1 with subsequent recruitment to Golgi membranes where mTORC1 gets activated by Rheb

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This vicious cycle of microbiota-induced ferroptosis ultimately leads to intestinal barrier disruption, pathogen translocation, and sustained amplification of the inflammatory cascade