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As use of GLP-1 receptor agonists continues to expand, the integration of conventional clinical evidence with large-scale observational data may offer a more complete picture of how these therapies affect patients in routine practice

These medications are not FDA-approved for safety or effectiveness but may be used when alternatives are not available or appropriate

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Symptoms include intense burning or stinging at the site, skin that shifts from pale to red to blistered, and in severe cases, tissue death

It works through the central nervous system rather than blood flow