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hCG is a thyroid stimulator and most transient non-immune hyperthyroidism in early pregnancy is related to increased hCG levels while rare cases of familial recurrent gestational hyperthyroidism are caused by a mutant thyrotropin receptor that is hypersensitive to hGC as has been reported with even normal range serum hCG [70]

Lower efficacy agonists, notably morphine, quite inefficiently phosphorylate some residues in the same C-terminal region when compared with DAMGO (Doll et al., 2011

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