Instead, our findings demonstrate an important role for GSH in the liver, where under resting conditions, GSH maintains low NRF2 activity to permit ample expression of lipogenic enzymes, promotes the production of triglycerides, and sustains lipid abundance in vivo
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Studies have shown that asymptomatic individuals with hyperuricemic already exhibit subclinical inflammation (e.g., elevated IL-6 and CRP), whereas acute gout flares are characterized by significant increases in IL-1 and S100A8/A9 levels, which may serve as distinguishing biomarkers (Ohashi et al., 2024
1.2 Pathophysiology and mechanisms of DN DN is a significant microvascular complication of diabetes mellitus, characterized by a range of nerve dysfunctions that can lead to debilitating symptoms such as pain, numbness, and other neurological impairments
