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Given the progressive nature of Put-GABA down-regulation in DA/GABA striatal neurons with chronic ethanol consumption, as well as potential diversion of these nitrogen substrates toward NO synthesis (Figure 1), it could be worthwhile to examine whether promoting polyamine synthesis in striatal DA/GABA neurons impacts ethanol withdrawal symptoms

By moving these substances to Category 2, the FDA is signaling that the current body of evidence is insufficient to guarantee their safety and efficacy when compounded in bulk

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