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Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation

600 mg/d) may be one of the factors influencing motor function in patients with PD

Doses are usually low and delivered in short pulses or continuous infusion based on effect needed, which makes stimulation targeted and controllable compared to more general agents

Compounding industry groups have challenged this position, arguing that the salt form dissociates in solution and delivers the same therapeutic molecule

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