The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses
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10.2119/2008-00035.Gribar 64 Guzman-MartinezL.MaccioniR
This chemokine acts on Th1 cells, eosinophils, and mast cells to promote immune cell infiltration and epidermal hyperplasia, which functions as a mediator linking acute and chronic phases, as supported by its upregulation across disease stages (Yu et al., 2020
Symptoms can include bluish discoloration of the skin, shortness of breath, fatigue, and confusion