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In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop

Storing peptides in a refrigerator, ideally at 2C to 8C, is suggested to prevent degradation

Dihexa is a hexapeptide with potent neurotrophic activity

3.2 Quality assessment and risk of bias According to the Jadad scale for RCTs (n = 13) (Tanaka et al., 1981

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