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To create the glutathione model used in this paper, we took the model from [11] and added the glutathione pathway, homocysteine, cystathionine, cysteine, glutamylcysteine, GSH, and GSSG [Figure 1] from a previous model of glutathione metabolism [14]

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1 Introduction Non-alcoholic fatty liver disease (NAFLD) has evolved into a global epidemic, currently affecting approximately 30% of the adult population worldwideequating to over two billion individualsand its prevalence continues to rise in parallel with the global surge in obesity and type 2 diabetes (T2DM) (Powell et al., 2021)

(Lausanne) 13 , 846903 (2022)