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Second, many clinical trials are of relatively short duration (often 6 months), failing to capture the long-term efficacy and sustainability of interventions on OA progression, a inherently chronic disease

In general, many of the anticancer effects of curcumin are related to the simultaneous modulation of several epigenetic mechanisms, with studies suggesting the negative regulation or inhibition of DNMTs and HDACs jointly by this polyphenol (Shu et al., 2011)

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This will suppress the proliferation and also induce the apoptosis of endometriotic cells by unleashing caspase-3

Gastroenterology 162 , 548561.e4 (2022)