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Other lipophilic compounds, including neuromuscular blockers like vecuronium and rocuronium, also show prolonged durations of action in females

HGF is the sole ligand for c-Met, and HGF binding with c-Met can lead to c-Met phosphorylation, which activates several intracellular signaling pathways, including MAPK, STAT3, and PI3K/AKT

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This is because of perspiration or friction which may also play a contributory role, as suggested by the predilection of acanthosis nigricans for body folds

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