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To view a copy of this license, visit About this article Cite this article Kumar, J., Liddle, E.B., Fernandes, C.C

3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )

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In another study, the incidence of a vitamin B12 deficiency was 27% in people with hypothyroidism, 17% in patients with subclinical hypothyroidism, and 18% in those with autoimmune thyroid disease

Doctors might change this based on how well the patient is doing