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Lastly, for patients with significant high-end metabolic issues, sleep apnea, heart disease, uncontrolled hypertension, or immobility due to high BMI, GLP-1s alone may not be enough

Researchers investigate GLP-1 signaling to better understand mechanisms involved in glucose homeostasis, cellular energy balance, gastrointestinal signaling, and inter-organ communication

Its not that the medicine didnt work, Aronne said

Read more about GLP-1s at drugs.com