Potential Benefits & Observed Effects Documented effects from research literature and clinical observations
While GLP-1 and GIP receptor agonists are highly effective for initiating caloric deficits, human metabolism is highly adaptive
cAMP directly activates protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 2 (Epac2), that act in concert to generate downstream signals resulting in increased insulin secretion 8
When GLPs do their thing and reduce food cravings and obsessing, and slow down the reward pathway, individuals tend to describe this as less food noise in their head
Kalinin, A.E., Kalinin, A.E., Aho, M., Uitto, J