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10.1161/CIRCRESAHA.113.279984 238 WuC.-Y.YangY.-H.LinY.-S.ChangG.-H.TsaiM.-S.HsuC.-M.et al (2021)

GLP-1 works in the following ways: It stimulates the pancreas to release insulin (which lowers blood glucose), suppresses the release of glucagon (a hormone that raises blood glucose)

A: In a 2023 Phase 2 trial, participants on the highest dose (12 mg) lost an average of 24.2% of their body weight over 48 weeks, and they had not yet reached a weight loss plateau