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In further embodiments, the tonicity agents are present in an amount as to provide a final osmolality of an otic formulation or composition of about 100 mOsm/kg to about 500 mOsm/kg, from about 200 mOsm/kg to about 400 mOsm/kg, from about 250 mOsm/kg to about 350 mOsm/kg or from about 280 mOsm/kg to about 320 mOsm/kg

This study, lasting 68 weeks, assesses the efficacy and safety of subcutaneous CagriSema (a fixed-dose combination of cagrilintide 2.4 mg and semaglutide 2.4 mg) in comparison to its individual components: cagrilintide 2.4 mg, semaglutide 2.4 mg, and a placebo, all administered weekly

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This suggests the dual mechanism might provide additional appetite control beyond GLP-1 alone