Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome
The standard regimen involves 1 mg (1000 g) administered intramuscularly on alternate days until there is no further improvement in symptoms, followed by maintenance injections of 1 mg every two months
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These can include mild soreness or bruising at the injection site, dizziness, or in very rare cases, allergic reactions
Women with hormonal imbalances should consult healthcare providers before starting treatment