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Clinical indications commonly include bothersome vasomotor symptoms, genitourinary syndrome of menopause, primary ovarian insufficiency, or hypoestrogenism secondary to surgical menopause in appropriately screened patients

While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

Bibcode:1994ApEnM..60.1495K

This mechanism works in a complementary direction to the dermal papilla proliferation effect

However, treatment should not be delayed whilst awaiting test results if clinical suspicion is high, particularly when neurological symptoms are present