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For example, older adults may have a more challenging time absorbing supplements due to changes in digestive function that occur with age

Mol Asp Med 32(46):223233 Ishikawa H, Takaki A, Tsuzaki R, Yasunaka T, Koike K, Shimomura Y, Seki H, Matsushita H, Miyake Y, Ikeda F, Shiraha H, Nouso K, Yamamoto K (2014) L-Carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway

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However, we note that the in vivo contribution of actin remodelling to skeletal muscle GLUT4 translocation may not be as great as observed in vitro , since muscle-specific knockout of both - and - actin isoforms in adult mice had limited impact on insulin-stimulated glucose transport [88,89]