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Besides the initial short-lasting increase of intraocular pressure upon retrobulbar application, which appeared equally upon retrobulbar application of saline, L-NAME, and BPC 157 (Figure 1), intraocular pressure was continuously normal, and it was not otherwise changed upon application of BPC 157 or saline (the data are not specifically shown)

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Conclusions This study establishes a novel and critical molecular mechanism for the pharmacological actions of BPC157, centered on the BPC157-FBXO22-BACH1 axis