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By the time Novo Nordisk applied to market liraglutide for obesity, two of its chemists, Jesper Lau and Thomas Kruse (figure 38) were looking into how to improve it

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In contrast, in advanced stages, persistent ischemia/hypoxia and subsequent reperfusion may lead to a decrease in fatty acid oxidation and an increase in that of glucose oxidation, which further contributes to lipotoxicity, lactic acidosis, low ATP production, contractile dysfunction, and progression to HF