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doi: 10.3390/toxins10040155 62

The ability to return to activities abandoned due to chronic pain, improved quality of life, and sustained relief rather than temporary symptom reduction characterize successful long-term protocols

gingivalis can produce SCFAs through proteolysis, and the concentration of SCFAs in the gingival crevicular fluid (GCF) of periodontitis patients is positively correlated with periodontal clinical indicators (probing depth, bleeding index, attachment loss)

PMID 16511441

sEV have the ability to merge with adjacent RA-FLS, resulting in an increase in the production of forkhead box-O1 and its downstream factor, vascular endothelial growth factor