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Nadkarni GN, Ferrandino R, Chang A, Surapaneni A, Chauhan K, Poojary P, Saha A, Ferket B, Grams ME, Coca SG

Cell death is a consequence of the decrease in ATP production which rapidly compromises ion (mainly due to halting Na + -K + pump) and acid-base homoeostasis

arSi90[lag-2p::apx-1(KtoR)] is a single copy insertion on the LGI site generated from pJC120 with all the intracellular lysines (4 lysines) mutated to arginine

10.1016/j.neubiorev.2010.07.001 15 FiandacaM

Conditions such as Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Fibromyalgia (FM), and Gulf War Syndrome (GWS) are examples of these chronic illnesses that are triggered by different factors but share overlapping clinical symptoms, in particular profound fatigue (see Figure 1)