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Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, magnesium deficiency, and higher serum levels of glutamate (13, 14)

Measure biomarkers like glutathione peroxidase activity, malondialdehyde, or total antioxidant capacity before and after 812 weeks of supplementation

Available from: McDowell LR

Although the anti-Met macrocycles described above might be incapable of inducing dimerization, we reasoned that they might be rendered chemically amenable to induction of dimerization via an appropriate cross-linker (Fig

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