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Farnesoid X receptor activation by the novel agonist TC-100 (3, 7, 11-Trihydroxy-6-ethyl-5-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow

The diffraction images were deposited to Integrated Resource for Reproducibility in Macromolecular Crystallography 88 ( and can be accessed via PDB 8AGQ

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Vitamin B12 also plays a key role in reducing levels of an amino acid called homocysteine, high levels of which have been linked to chronic conditions like heart disease, stroke, and Alzheimers

Aging and degeneration of the human intervertebral disc