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Balancing the Walsh Protocol with Folinic Acid Therapy in Autism The Walsh Protocol typically avoids folate supplementation in individuals with autism because most autistic individuals are undermethylators, a condition characterized by low serotonin activity and high SERT (serotonin transporter) expression, leading to excessive serotonin clearance
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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Sandsdal R.M., Juhl C.R., Jensen S.B.K., Lundgren J.R., Janus C., Blond M.B., et al