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GLP-1RAs may increase C-X-C motif chemokine ligand 12 (CXCL12) [10], which is associated with VEGF-mediated angiogenesis [11]

This insufficiency can lead to symptoms like muscle weakness, clumsiness, vomiting, and confusion

Many of these therapeutic strategies applied in CKD management have focused mainly on lifestyle changes (including dietary patterns and exercise), biotics intervention (probiotics, prebiotics, and synbiotics), and FMT (Figure 3)

Key take: GLP-1s represent a new frontier, signaling the dawn of real preventive and longevity medicine, but theres still a long road before we see longevity drugs for everyone

Reduces Toxin Reabsorption The Catch phase emphasizes gastrointestinal binding to limit enterohepatic recirculation and promote fecal elimination