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GLP-1 receptor agonists, synthetic analogs of native GLP-1, emulate these actions with a tactical advantage they are resilient to the rapid degradation by the enzyme DPP-4, thus extending their physiological influence

What was once a stepwise sequence: metformin, sulfonylurea, insulin: has become a personalised choice, with classes (GLP-1 receptor agonists, SGLT2 inhibitors, dual GIP/GLP-1 agonists) chosen as much for cardiovascular and renal protection as for blood-glucose control

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E., & Frias, J

GLP-1s also slows the rate at which your stomach empties which leads to an increase in the feeling of fullness