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For patients who have had a cardiovascular event and heart failure, SGLT2 inhibitors are recommended as first-line treatment, GLP-1 RAs or metformin as second-line treatment, and DPP4 inhibitors, acarbose, or insulin as third-line treatment [5]

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Further investigation revealed that the use of fatty di-acids longer than 14 carbons attached via Glu resulted in loss of activity, while the use of mono-acids of up to 16 carbons (palmitate) retained activity, as shown in Table 1

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Dark urine, dizziness, or headaches can be signs you need more fluids