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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

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To learn more about the powerful roles of Glutathione and NAC, please check out this review article

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Xiao L., Harrison D.G