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Often chosen, this approach is speedier and more easily observable

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More recently, a family of potent and highly selective mechanism-based suicide substrate inhibitors were developed and shown to promote the irreversible inhibition of gut microbiotadependent generation of TMA, suppression of host TMAO levels, and, in parallel, inhibition of platelet hyperresponsiveness and thrombosis potential in animal models (22)

Rabbit polyclonal anti-cleaved caspase-3 antibody (AB3623) was obtained from Merck Millipore (Darmstadt, Germany), and rabbit polyclonal anti-GFAP antibody (ab7260) was bought from Abcam (Cambridge, UK)