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183 Indeed, research has shown that high salt conditions can inhibit tumor growth by enhancing antitumor immunity, particularly through the modulation of MDSC functions

However, none of these drugs are approved for the treatment of PFIC by the European Medicines Agency (EMA) (except for UDCA, which is approved in France for the treatment of PFIC3) [14] and their efficacy is debated [1], being often unable to avoid disease progression and listing for LT [6, 8]

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