In the absence of randomized controlled trials, it is impossible to conclude that paricalcitol treatment is superior to calcitriol or alfacalcidol in terms of patient survival
Some people may experience mild digestive upset or bloating when first starting, especially if they are taking a high dose
Product quality from unregulated vendors is a separate, underappreciated risk
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When the gut environment is calm, vagal tone improves, shifting the autonomic nervous system away from the hyper-aroused "fight or flight" sympathetic state and toward the restorative "rest and digest" parasympathetic state