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5 Unit of Pharmacology, Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kuala Lumpur, 57000, Malaysia Correspondence: Shubha Singhal, Department of Pharmacology, All India Institute of Medical Sciences-Rajkot, Ayush Block, Khanderi, Para Pipaliya, Rajkot, Gujarat, India, Tel +91 9560372056, Email [email protected] Mainul Haque, Unit of Pharmacology, Faculty of Medicine and Defence Health Sciences, Universiti Pertahanan Nasional Malaysia, National Defence University of Malaysia- Kem, Perdana, Sungai Besi, Kuala Lumpur, 57000, Malaysia, Tel +60 109265543, Email [email protected] Abstract: Metformin has been designated as one of the most crucial first-line therapeutic agents in the management of type 2 diabetes mellitus

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