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Up to 75% of adults will experience hemorrhoids by age 50, with pregnancy, chronic constipation, and prolonged sitting increasing risk due to increased pressure on anal veins

While insurers receive rebates to offset some of their costs, the list prices of GLP-1 drugs are about $1,000 per month, and growing demand for these medications could put upward pressure on premiums

Moreover, SCFAs play critical roles in energy metabolism, which are essential for supporting B cell activation, differentiation, and antibody synthesis (85)

ERAD elicits diverse functions by impacting gene transcription and protein translation