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Most of these studies were very short and could not identify a target with important clinical result for the patients (e.g., noncompensated liver cirrhosis), instead referring to certain objective findings, e.g., levels of aminotransferases or histologic findings, often with conflicting results
With dual and triple agonists under development, how do we determine the optimal balance of hormones in combination therapies to maximize efficacy while minimizing side effects
Notably, as a crucial cytosolic pattern recognition receptor, the NLRP3 inflammasome detects diverse stimuli, including microbial pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), while also responding to metabolic disturbances such as hyperglycemia and free fatty acids (Zangara et al., 2021)
Maintaining energy homeostasis requires substrate sensing, trafficking storage and utilization, dependent on substrate availability and energy requirement [4,18]
