The SC administration across different dose groups in the FIH study out of a vial would be achieved by administering: Different volumes, such as using disposable syringes with or without SC clinical pumps Using a placebo/diluent formulation to dilute to the respectively required concentrations and then administering similar volume, such as by using a disposable syringe with or without SC clinical pumps
Giustarini D, Colombo G, Garavaglia ML, Astori E, Portinaro NM, Reggiani F, Badalamenti S, Aloisi AM, Santucci A, Rossi R, Milzani A, Dalle-Donne I (2017) Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells
Egypt J
Apply a small amount and cover the affected areas
(PubMed) Still, this is the first place where hype can outrun evidence