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For instance, a single dose of semaglutide or exenatide reduced circulating levels of tumor necrosis factor (TNF-) in mice challenged with lipopolysaccharide (LPS)

Reduced tolerance is a common report

This removes any ambiguity about when the medication needs to be replaced

Acknowledgements The authors would like to thank all the participants, investigators and trial site staff who were involved in the conduct of the trials

In a 68-week clinical study comparing Wegovy (semaglutide) with a placebo, about 69% of Wegovy users lost 10% or more of their body weight compared to 12% of placebo users who lost about the same body weight percentage