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Wild B, Hnnemeyer K, Sauer H, Schellberg D, Mller-Stich BP, Knigsrainer A, et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Ridderstrle M, Andersen KR, Zeller C, Kim G, Woerle HJ, Broedl UC

Specifically, TSH induces hepatic steatosis by activating sterol regulatory element-binding protein (SREBP) pathways, inhibits bile acid synthesis by suppressing the SREBP2hepatocyte nuclear factor 4 (HNF4)CYP7A1 axis, and attenuates cholesterol biosynthesis via AMP-activated protein kinase (AMPK)dependent phosphorylation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) (42)